Under 10ms round-trip: safe to monitor through the DAW while tracking.
10–20ms: noticeable for tracking, fine for mixing and production work.
Over 20ms: switch to direct monitoring on your interface — bypass the DAW entirely.
Most interfaces add 2–6ms hardware latency on top of the buffer. Check the spec sheet or measure with a loopback test.
Recording MIDI to software instruments: use the lowest buffer your CPU can hold without dropouts.
Mixing and rendering: push the buffer as high as possible (1024–2048) to free CPU headroom.
High sample rates halve the buffer latency — 128 samples at 96kHz = same ms as 64 samples at 48kHz.